EGFR-IN-209

Overview

EGFR-IN-209 (Compound 6g) is an orally active, selective EGFR Del19/T790M/C797S inhibitor with an IC 50 of 0.056 μM. EGFR-IN-209 blocks the phosphorylation of EGFR and its downstream effector molecules ( pMAPK , pAKT ). EGFR-IN-209 induces Apoptosis . EGFR-IN-209 exhibits antitumor activity against Osimertinib ( HY-15772 )-resistant non-small cell lung cancer . EGFR-IN-209 can be used in research related to non-small cell lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Akt

Product Information

• Catalog No.: HY-183277
• CAS No.: 3088042-00-3
• Molecular Formula: C21H25N5O
• Molecular Weight: 363.46
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source