FLLL12

Overview

FLLL12 (GO-Y026) is a curcumin analog anticancer agent. FLLL12 inhibits the phosphorylation of AKT , Bcl-2 , Bid , EGFR , mTOR , FOXO1a , FOXO3a , STAT3 , HER2/neu , as well as pancreatic AKT/STAT3; upregulates the expression of Bim and DR5 ; and activates PTPs . FLLL12 regulates downstream pathways, induces mitochondria-mediated and DR5-dependent extrinsic apoptosis , inhibits cancer cell viability, proliferation, anchorage-independent growth and migration, and exerts a synergistic effect with Doxorubicin ( HY-15142A ). FLLL12 can be used in research related to head and neck squamous cell carcinoma, breast cancer , prostate cancer , pancreatic cancer , lung cancer , colon cancer and colorectal cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Pancreatic Cancer | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Stem Cell/Wnt | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > EGFR | Products > Signaling Pathways > mTOR | Products > Signaling Pathways > FOXO | Products > Signaling Pathways > STAT | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Phosphatase | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Bcl-2 Family

Product Information

• Catalog No.: HY-183402
• CAS No.: 917813-60-6
• Molecular Formula: C21H22O7
• Molecular Weight: 386.40
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source