KBJK557

Overview

KBJK557 is a Plk1 PBD inhibitor with a human-derived IC 50 value of 3.05 μM. KBJK577 binds to Plk1 PBD through electrostatic interactions, π-π stacking, hydrogen bonds, salt bridges and hydrophobic interactions, thereby disrupting the subcellular localization and function of Plk1 . KBJK557 induces mitotic arrest, S-phase delay, G2/M-phase arrest and apoptosis , and inhibits cancer cell proliferation. KBJK557 can be used in research related to cancer and non-small cell lung cancer .

Application

Products | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Polo-like Kinase (PLK) | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-183427
• CAS No.: 2660138-04-3
• Molecular Formula: C24H22N6O4
• Molecular Weight: 458.47
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source