INCB191358

Overview

INCB191358 is a selective and orally active inhibitor of diacylglycerol kinase α/ζ/ι ( DGKα/ζ/ι ) with IC 50 values of 0.12, 0.36 and 0.36 nM. INCB191358 induces antigen-dependent T-cell activation, induces IL-2 production and enhances antitumor efficacy in combination with PD-1 blockade. INCB191358 can be used for the research of cancer , such as colon carcinoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DGK | Products > Signaling Pathways > Interleukin Related

Product Information

• Catalog No.: HY-183539
• CAS No.: 3111036-70-2
• Molecular Formula: C25H30F3N5O3
• Molecular Weight: 505.53
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source