YO-2 is a plasmin inhibitor and TP53 upregulator with anti-tumor and apoptosis -inducing activities. YO-2 upregulates the expression of TP53 and the tumor-suppressive miR-103/107 , downregulates LRP1, and induces cellular DNA fragmentation and caspase cascade activation. YO-2 effectively blocks the growth of melanoma. YO-2 has been widely used in studies related to melanoma and colon cancer .
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