NPA101.3

Overview

NPA101.3 is an orally active RET receptor tyrosine kinase and VEGFR2 inhibitor ( RET IC 50 = 0.001 μM, RET V804M IC 50 = 0.008 μM, VEGFR2 IC 50 = 0.003 μM). NPA101.3 inhibits purified TRKA ( IC 50 = 32 nM) and CSF1R ( IC 50 = 46 nM). NPA101.3 completely suppresses tumor formation in RET /C634Y -transformed cells and also attenuates tumor formation in HRAS /G12V -transformed cells. NPA101.3 can be used in the research of RET -driven cancers.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > RET | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Trk Receptor | Products > Signaling Pathways > c-Fms

Product Information

• Catalog No.: HY-183931
• CAS No.: 1839155-15-5
• Molecular Formula: C29H28N4O4S
• Molecular Weight: 528.62
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source