PKF 242-484

Overview

PKF 242-484 (TNF484) is an orally active dual inhibitor of TACE/MMPs , with K i values of 3.6, 0.1, 0.9, 1, and 4.5 nM against hMMP-1 , hMMP-2 , hMMP-3 , hMMP-9 , and hMMP-13 , respectively. PKF 242-484 inhibits the enzymatic activities of MMPs and ADAM17 , reduces the release of TNF-α , suppresses the proliferation, migration and invasion of cancer cells, and regulates inflammatory cell infiltration and cytokine production. PKF 242-484 can be used in studies related to airway inflammatory diseases such as asthma and chronic obstructive pulmonary disease, intestinal ischemia-reperfusion injury, epilepsy-induced neuronal damage, and hepatocellular carcinoma.

Application

Products | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Oxidative Stress and Inflammation | Products > Disease Areas > Nervous System Injury | Products > Disease Areas > Pulmonary Disease | Products > Disease Areas > Chronic Disease and Inflammation | Products > Disease Areas > Respiratory Inflammation | Products > Disease Areas > Lower Respiratory Inflammation | Products > Disease Areas > Liver Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Epilepsy | Products > Disease Areas > Ischemia-Reperfusion Injury | Products > Disease Areas > Chronic Obstructive Pulmonary Disease | Products > Disease Areas > Asthma | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Respiratory Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > MMP | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-184087
• CAS No.: 205807-59-6
• Molecular Formula: C19H29N3O6
• Molecular Weight: 395.45
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source