GCLCi1

Overview

GCLCi1 is an orally active glutamate-cysteine ligase catalytic subunit ( GCLC ) inhibitor and ferroptosis inducer. GCLCi1 blocks the rate-limiting step of glutathione synthesis, leading to GSH depletion, elevated reactive oxygen species and lipid peroxidation. GCLCi1 exhibits high selectivity for SMARCB1 -deficient cancer cells and possesses anti-tumor activity. In addition, the combination of GCLCi1 with SLC7A11 inhibitors and Telaglenastat ( HY-12248 ) produces a synergistic effect, which can be used for the research of smarcb1-deficient malignant rhabdoid tumors and smarcb1-deficient epithelioid sarcomas.

Application

Products | Products > Disease Areas > Cancer | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy

Product Information

• Catalog No.: HY-184267
• CAS No.: 2926699-78-5
• Molecular Formula: C8H15F3N2O4S
• Molecular Weight: 292.28
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source