TH-407a

Overview

TH-407a is an orally active and selective USP15 inhibitor with an IC 50 of 0.76 μM. As an allosteric modulator, TH-407a binds to a non-catalytic site to block deubiquitinating activity. TH-407a inhibits cell growth, proliferation, clonogenicity and migration, regulates the p53 signaling pathway, and reduces the stability of PARP1 . TH-407a exhibits anti-tumor activity in breast cancer xenograft mouse models. TH-407a can be used for the research of breast cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Breast Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Deubiquitinase | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > PARP

Product Information

• Catalog No.: HY-184273
• CAS No.: 1903103-73-0
• Molecular Formula: C22H18N4O
• Molecular Weight: 354.40
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source