ANDS

Overview

ANDS (1-Amino-8-naphthol-2,4-disulfonic acid) is an orally active inhibitor of CaMKP ( IC 50 = 6.4 μM; K i = 3.6 μM) and CaMKP‑N ( IC 50 = 6.6 μM). ANDS binds unacetylated p53 and restores p53 activity by disrupting ANP32B-p53 interaction. ANDS inhibits chronic myeloid leukemia (CML) cell proliferation, impairs leukemic stem cells (LSC) function and prolongs survival in CML mouse model while sparing normal progenitor cells. ANDS can be used to study the eradication of LSCs and the overcoming of tyrosine kinase inhibitor (TKI) resistance in CML. ANDS can be used to study breast cancer .

Application

Products | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Blood Disease | Products > Disease Areas > Chronic Myelogenous Leukemia | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Signaling Pathways > Neuronal Signaling | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > CaMK | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Phosphatase

Product Information

• Catalog No.: HY-184486
• CAS No.: 16781-09-2
• Molecular Formula: C10H7NNa2O7S2
• Molecular Weight: 363.27
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source