RMC-8839

Overview

RMC-8839 is an orally active selective RAS (ON) G13C inhibitor with a K i value of 28.3 nM. RMC-8839 disrupts the interaction between KRAS G13C and RAF1 (RBD). RMC-8839 inhibits RAS - MAPK pathway signaling by reducing DUSP6 mRNA levels and pERK levels. RMC-8839 induces cytotoxicity, apoptosis ( apoptosis ) and antiproliferative effects in KRAS G13C -mutated cells. RMC-8839 induces tumor stasis or regression in mice. RMC-8839 can be used in research related to non-small cell lung cancer .

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Respiratory Disease | Products > Disease Areas > Lung Cancer | Products > Disease Areas > Respiratory Cancer | Products > Disease Areas > Non-Small Cell Lung Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Ras | Products > Signaling Pathways > Raf | Products > Signaling Pathways > PERK | Products > Signaling Pathways > p38 MAPK

Product Information

• Catalog No.: HY-184892
• CAS No.: 2953305-55-8
• Molecular Formula: C54H72F3N9O8
• Molecular Weight: 1032.20
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source