HM-279

Overview

HM-279 is a potent and orally active ALK5 inhibitor with an IC 50 of 4.7 nM. HM-279 shows cross-reactivity with ALK7 (IC 50 = 6.8 nM), but HM-279 has fair to good selectivity against other TGF-β receptor family kinases, with 4.5-693-fold selectivity. HM-279 demonstrates antitumor activity in vivo through CD8 + T cell immunity. HM-279 can be used for the research of colon cancer .

Application

Products | Products > Disease Areas > Immunotherapy for Colorectal Cancer | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Colorectal Cancer | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Cancer Immunology | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > TGF-β Receptor

Product Information

• Catalog No.: HY-185430
• CAS No.: 3039954-64-5
• Molecular Formula: C22H25N7O2S
• Molecular Weight: 451.54
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source