(S)-HDAC-IN-102 is a HDAC8 inhibitor and an isomer of HDAC-IN-102 ( HY-185554 ). HDAC-IN-102 inhibits total HDAC with an IC 50 of 58 μM and exhibits partial subtype selectivity. Specifically, (S)-HDAC-IN-102 targets HDAC8 , while (R)-HDAC-IN-102 ( HY-185554B ) targets HDAC2 . HDAC-IN-102 exerts antioxidant effects by scavenging DPPH free radicals and can be used in cancer-related research.
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