PKI-179 hydrochloride

Overview

PKI-179 hydrochloride is a potent and orally active dual PI3K/mTOR inhibitor, with IC 50 s of 8 nM, 24 nM, 74 nM, 77 nM, and 0.42 nM for PI3K-α , PI3K-β , PI3K-γ , PI3K-δ and mTOR , respectively. PKI-179 hydrochloride also exhibits activity over E545K and H1047R , with IC 50 s of 14 nM and 11 nM, respectively. PKI-179 hydrochloride shows anti-tumor activity in vivo.

Application

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Product Information

• Catalog No.: HY-11080A
• CAS No.: 1463510-35-1
• Molecular Formula: C25H29ClN8O3
• Molecular Weight: 525.00
• Purity: 99.66%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
• Solubility: ≥ 1.25 mg/mL (2.38 mM); Clear solution
• Availability: In-stock

Source

Original product source