3'-Methoxy-4'-nitroflavone

Overview

3'-Methoxy-4'-nitroflavone (MNF) is a specific aryl hydrocarbon receptor ( AhR ) antagonist. 3'-Methoxy-4'-nitroflavone activates AhR by inhibiting CYP1 , the metabolic enzyme of the endogenous ligand FICZ ( HY-12451 ), leading to the accumulation of FICZ . 3'-Methoxy-4'-nitroflavone reverses the anti- apoptotic effect of TCDD, attenuates the activation of Akt and Erk1/2 kinases and the expression of TGFα induced by TCDD. 3'-Methoxy-4'-nitroflavone can be used in research related to breast tumor promotion, rheumatoid arthritis, multiple sclerosis and inflammatory bowel disease.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Neurodegenerative Disease | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Arthritis | Products > Disease Areas > Breast Cancer | Products > Disease Areas > Multiple Sclerosis | Products > Disease Areas > Inflammatory Bowel Disease | Products > Disease Areas > Rheumatoid Arthritis | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > TGF-beta/Smad | Products > Research Areas > Neurological Disease | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Cytochrome P450 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > ERK | Products > Signaling Pathways > TGF-beta/Smad | Products > Signaling Pathways > Aryl Hydrocarbon Receptor

Product Information

• Catalog No.: HY-20888
• CAS No.: 145370-39-4
• Molecular Formula: C16H11NO5
• Molecular Weight: 297.26
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source