Phaeosphaeride A

Overview

Phaeosphaeride A is a STAT3 inhibitor with an IC 50 of 0.61 mM against human STAT3 . It exhibits higher selectivity for STAT3 over STAT1 and STAT5 . Phaeosphaeride A inhibits the binding of STAT3 to DNA, STAT3 -dependent transcriptional activity, as well as IL-6 -induced phosphorylation and signaling of STAT3 . Phaeosphaeride A activates the JNK , p38 , Akt , CREB and STAT5A/B signaling pathways. Phaeosphaeride A induces oxidative stress ( ROS ), exerts antiproliferative and growth-inhibitory effects in cancer cells, and shows low cytotoxicity toward non-cancerous cells. Phaeosphaeride A is a phytotoxin and a weak animal toxin, with no antimicrobial activity against tested bacteria and fungi. Phaeosphaeride A can be used in research related to conditions such as cervical cancer and multiple myeloma, as well as weed infestations.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Blood or Cardio-cerebrovascular Disease | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Leukemia/Lymphoma/Myeloma | Products > Disease Areas > Cervical Cancer | Products > Disease Areas > Urogenital Cancer | Products > Disease Areas > Blood Disease | Products > Disease Areas > Multiple Myeloma | Products > Signaling Pathways > JAK/STAT Signaling | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > NF-κB | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > JNK | Products > Signaling Pathways > p38 MAPK | Products > Signaling Pathways > Akt | Products > Signaling Pathways > Reactive Oxygen Species (ROS) | Products > Signaling Pathways > STAT

Product Information

• Catalog No.: HY-N19899
• CAS No.: 910050-51-0
• Molecular Formula: C15H23NO5
• Molecular Weight: 297.35
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source