GPR35 agonist 6

Overview

GPR35 agonist 6 is a potent and selective agonist targeting GPR35 , with an EC 50 of 12.1 nM against human GPR35 . GPR35 agonist 6 activates the human splice variant GPR35b with comparable efficacy, showing an EC 50 of 22.1 nM. GPR35 agonist 6 also exhibits weak GPR55 antagonistic activity, with an IC 50 of 21.7 μM, and its agonistic activity towards GPR35 is significantly stronger than its antagonistic activity towards GPR55 . GPR35 agonist 6 initiates GPR35 downstream signaling by inducing β-arrestin recruitment. GPR35 agonist 6 is used to investigate GPR35-mediated diseases, such as gastrointestinal lesions and gastric cancer .

Application

Products | Products > Disease Areas > Digestive System Cancer | Products > Disease Areas > Gastric Disease | Products > Disease Areas > Cancer | Products > Disease Areas > Digestive System Disease | Products > Disease Areas > Gastric Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > Neuronal Signaling | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > GPR35 | Products > Signaling Pathways > GPR55 | Products > Signaling Pathways > Arrestin

Product Information

• Catalog No.: HY-W1058476
• CAS No.: 1443367-20-1
• Molecular Formula: C18H12BrNO6
• Molecular Weight: 418.20
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source