TM-2-51

Overview

TM-2-51 is a HDAC8 activator with a K d value of 0.28 μM. TM-2-51 inhibits α-glucosidase with an IC 50 of 171.21 μM. TM-2-51 upregulates HDAC8 expression, modulates the TP53 , STAT3/ERK and PI3K-AKT pathways, alleviates LeTx-induced cell cycle arrest, downregulates JMJD3 and increases H3K27me3 levels. TM-2-51 selectively induces apoptosis in tumor cell and upregulates p53/p21 expression. TM-2-51 inhibits tumor cell proliferation, migration and invasion, induces G 1 -phase arrest and suppresses tumor growth in vivo. TM-2-51 can be used in research on osteosarcoma, anthrax, type 2 diabetes and neuroblastoma.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Metabolic or Endocrine Disease | Products > Disease Areas > Musculoskeletal and Skin Disease | Products > Disease Areas > Glucose Metabolism | Products > Disease Areas > Neuroblastoma | Products > Disease Areas > CNS Neoplasm | Products > Disease Areas > Osteosarcoma | Products > Disease Areas > Type 2 Diabetes | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Neurological Disease | Products > Research Areas > Metabolic Disease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Akt | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Apoptosis | Products > Signaling Pathways > HDAC | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-W274807
• CAS No.: 4921-82-8
• Molecular Formula: C14H12N2OS
• Molecular Weight: 256.32
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source