Romaciclib monohydrochloride

Overview

SEL120-34A monohydrochloride is an ATP-competitive and selective CDK8 inhibitor, inhibits kinase activities of CDK8/CycC and CDK19/CycC complexes with IC 50 s of 4.4 nM and 10.4 nM, respectively, with a K d of 3 nM for CDK8 . SEL120-34A monohydrochloride weakly inhibits CDK9 (calculated IC 50 =1070 nM), but shows no obvious activity against CDK1 , 2, 4, 6, 5, 7. SEL120-34A monohydrochloride inhibits phosphorylation of STAT1 S727 and STAT5 S726. Has anti-tumor activity.

Application

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Product Information

• Catalog No.: HY-111388A
• CAS No.: 2443816-41-7
• Molecular Formula: C15H19Br2ClN4
• Molecular Weight: 450.60
• Purity: 99.29%
• Storage: 4°C, sealed storage, away from moisture * In solvent : -80°C, 2 years; -20°C, 1 year (sealed storage, away from moisture)
• Solubility: ≥ 1.67 mg/mL (3.71 mM); Clear solution
• Availability: In-stock

Source

Original product source