BSc5371 is a potent and irreversible FLT3 inhibitor, with K d s of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3 (D835H), FLT3 (ITD, D835V), FLT3 (ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. BSc5371 is cytotoxic to FLT3-dependent cell lines.
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