(1R)-IDH889

Overview

(1R)-IDH889 is the isomer of IDH889 ( HY-112289 ), and can be used as an experimental control. IDH889 is an orally available, brain penetrant, allosteric and mutant specific inhibitor of isocitrate dehydrogenase 1 ( IDH1 ) . IDH889 has potent selectivity for IDH1 R132* mutations, with IC 50 s of 0.02 μM, 0.072 μM and 1.38 μM for IDH1 R132H , IDH1 R132C and IDH1 wt , respectively. IDH889 shows potent cellular inhibition of R-2-hydroxyglutarate (2-HG) production with an IC 50 of 0.014 μM.

Application

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Product Information

• Catalog No.: HY-112289B
• CAS No.: 1429179-08-7
• Molecular Formula: C23H25FN6O2
• Molecular Weight: 436.48
• Purity: 98.83%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 5 mg/mL (11.46 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source