Aloisine A

Overview

Aloisine A (RP107) is a a potent cyclin-dependent kinase ( CDK ) inhibitor with IC 50 s of 0.15 μM, 0.12 μM, 0.4 μM, 0.16 μM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E, CDK5/p35, respectively. Aloisine A ininhibits GSK-3α ( IC 50 =0.5 μM) and GSK-3β ( IC 50 =1.5 μM). Aloisine A stimulates wild-type CFTR and mutated CFTR , with submicromolar affinity by a cAMP-independent mechanism. Aloisine A has the potential for CFTR-related diseases, including cystic fibrosis research.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > PI3K/Akt/mTOR | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Membrane Transporter/Ion Channel | Products > Research Areas > Inflammation/Immunology | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > JNK | Products > Signaling Pathways > CFTR | Products > Signaling Pathways > CDK | Products > Signaling Pathways > GSK-3 | Products > Signaling Pathways > ERK

Product Information

• Catalog No.: HY-112363
• CAS No.: 496864-16-5
• Molecular Formula: C16H17N3O
• Molecular Weight: 267.33
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.
• Availability: In-stock

Source

Original product source