(3S,4R)-ME-344

Overview

(3S,4R)-ME-344 is the (3S,4R)-enantiomer of ME-344 ( HY-112749 ). ME-344 is a mitochondrial Heme oxygenase 1 ( HO-1 ) inhibitor. ME-344 specifically binds and alters HO-1 structure, and increases HO-1 translocation from the rough endoplasmic reticulum to mitochondria, but only in drug-sensitive cells (such as H460 and SHP-77 cells). ME-344 decreases mitochondrial ATP production and induces ROS , with subsequent disruption of redox homeostasis and mitochondrial function. ME-344 has significant antitumor activity, and can be used for cancers like breast cancer research.

Application

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Product Information

• Catalog No.: HY-112749B
• CAS No.: 1374524-84-1
• Molecular Formula: C22H20O4
• Molecular Weight: 348.39
• Purity: 98.04%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.5 mg/mL (7.18 mM); Clear solution
• Availability: In-stock

Source

Original product source