GNE-6640 is a selective and non-covalent inhibitor of ubiquitin epecific peptidase 7 ( USP7 ) , with IC 50 values of 0.75 μM, 0.43 μM, 20.3 μM and 0.23 μM for full length USP7 , USP7 catalytic domain, full length USP47 and Ub-MDM2, respectively.
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