GSK8814

Overview

GSK8814 is a potent and selective ATAD2 bromodomain chemical probe and inhibitor ( IC 50 = 0.059 μM), with a binding constant pK d = 8.1 and a pK i = 8.9 in BROMOscan. GSK8814 binds to ATAD2 and BRD4 BD1 with pIC 50 s of 7.3 and 4.6, respectively. GSK8814 shows 500-fold selectivity for ATAD2 over BRD4 BD1. GSK8814 can be researched for cancer associated with ATAD2 bromodomain.

Application

Products | Products > Signaling Pathways > Epigenetics | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Epigenetic Reader Domain

Product Information

• Catalog No.: HY-114204
• CAS No.: 1997369-78-4
• Molecular Formula: C28H35F2N5O3
• Molecular Weight: 527.61
• Purity: 99.80%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source