SGC8158

Overview

SGC8158 is an inhibitor of PRMT7 and can be used to study the cellular function of PRMT7 . SGC8158 decreases monomethylarginine levels of Hsp70 (the best characterized PRMT7 substrate). SGC8158 induces growth inhibition in various cancer cells (IC 50 : 2-9 μM), as well as multidrug-resistant (MDR) cancer cells. SGC8158 also enhances Doxorubicin ( HY-15142A ) induced DNA damage and Its cytotoxicity.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Epigenetics | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer > Cancer Drug Resistance | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Signaling Pathways > Histone Methyltransferase | Products > Signaling Pathways > HSP

Product Information

• Catalog No.: HY-114211
• CAS No.: 3062376-84-2
• Molecular Formula: C27H31ClN6O3S
• Molecular Weight: 555.09
• Purity: 97.6%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Availability: In-stock

Source

Original product source