EC1169

Overview

EC1169 is a cytotoxic maytansinoid conjugate that specifically binds to prostate-specific membrane antigen ( PSMA ). EC1169 precisely delivers the maytansinoid B hydrazide payload to PSMA -positive cells to exert antitumor activity. EC1169 only inhibits the growth of PSMA-positive cells but has no effect on PSMA-negative cells, and enables complete recovery in mice bearing PSMA-positive tumors. EC1169 exhibits safety with no body weight loss or major organ damage induced. EC1169 is used in studies of prostate cancer and other PSMA-expressing malignancies.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Urogenital Disease | Products > Disease Areas > Prostate Cancer | Products > Disease Areas > Urogenital Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Signaling Pathways > PSMA

Product Information

• Catalog No.: HY-114256
• CAS No.: 1610413-96-1
• Molecular Formula: C78H112N14O28S3
• Molecular Weight: 1790.00
• Purity: 98.06%
• Storage: -20°C, protect from light, stored under nitrogen * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
• Solubility: ≥ 2.5 mg/mL (1.40 mM); Clear solution
• Availability: In-stock

Source

Original product source