Tamnorzatinib

Overview

Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib ( HY-15772 ) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).

Application

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Product Information

• Catalog No.: HY-114358
• CAS No.: 1646839-59-9
• Molecular Formula: C32H26N4O6
• Molecular Weight: 562.57
• Purity: 98.59%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 1 mg/mL (1.78 mM); Clear solution
• Availability: In-stock

Source

Original product source