GGTI-286

Overview

GGTI-286, a potent and cell-permeable GGTase I inhibitor, is 25-fold more potent ( IC 50 =2 μM) than the corresponding methyl ester of FTI-276 ( HY-15873A ). GGTI-286 selectively inhibits geranylgeranylation of Rap1A over farnesylation of H-Ras in NIH3T3 cells ( IC 50 s =2 and >30 μM, respectively). GGTI-286 also potently inhibits oncogenic K-Ras4B stimulation with an IC 50 of 1 μM.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > GPCR/G Protein | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Immunotherapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Ras

Product Information

• Catalog No.: HY-115489
• CAS No.: 171744-11-9
• Molecular Formula: C23H31N3O3S
• Molecular Weight: 429.58
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source