Pentachloropseudilin ( Antibiotic A 15104 Y; PClP) is a reversible and allosteric potent inhibitor of Myo1s (class 1 myosins) with IC 50 s range from 1 to 5 μM for mammalian class-1 myosins and greater than 90 μM for class-2 and class-5 myosins. Pentachloropseudilin is a potent inhibitor of transforming growth factor-β ( TGF-β ) -stimulated signaling, with an IC 50 of 0.1 to 0.2 μM for TGF-β .
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