EN219

Overview

EN219 is a moderately selective synthetic covalent ligand against an N-terminal cysteine (C8) of RNF114 with an IC 50 of 470 nM. EN219 inhibits RNF114-mediated autoubiquitination and p21 ubiquitination.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > E1/E2/E3 Enzyme

Product Information

• Catalog No.: HY-115715
• CAS No.: 380351-29-1
• Molecular Formula: C17H13Br2ClN2O
• Molecular Weight: 456.56
• Purity: 99.21%
• Storage: 4°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 3.25 mg/mL (7.12 mM); Clear solution
• Availability: In-stock

Source

Original product source