Cathepsin L-IN-2

Overview

Cathepsin L-IN-2 ((Rac)-Z-Phe-Phe-FMK) is an isomer of the Cathepsin L inhibitor Z-Phe-Phe-FMK ( HY-141867 ), with an IC 50 of 15 μM for cathepsin L . Z-Phe-Phe-FMK irreversibly blocks the proteolytic function of cathepsins by covalently binding to the cysteine residues in the active center of the enzyme. Cathepsin L-IN-2 and Z-Phe-Phe-FMK can be used to study neurodegenerative diseases (such as GRN-related frontotemporal dementia) and cancer invasion and metastasis.

Application

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Product Information

• Catalog No.: HY-115733
• CAS No.: 108005-94-3
• Molecular Formula: C27H27FN2O4
• Molecular Weight: 462.51
• Purity: 98.02%
• Storage: -20°C, sealed storage, away from moisture and light * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
• Solubility: ≥ 1.7 mg/mL (3.68 mM); Clear solution
• Availability: In-stock

Source

Original product source