MIF2-IN-1 (compound 5d) is a potent inhibitor of MIF2 tautomerase with an IC 50 of 1.0 μM. MIF2-IN-1 suppresses the proliferation of non-small cell lung cancer cells by the induction of cell cycle arrest via deactivation of the MAPK pathway. MIF2-IN-1 has the potential for the research of cancer diseases.
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