K783-0308

Overview

K783-0308 is a potent and selective dual inhibitor of FLT3 and MNK2 with IC 50 values of 680 and 406 nM, respectively. K783-0308 inhibits the growth of MOLM-13 (IC 50 =10.5 µM) and MV-4-11 (IC 50 =10.4 µM) cells. K783-0308 promotes acute myeloid leukemia (AML) cell apoptosis and cell cycle arrests in the G0/G1 phase.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > MAPK/ERK Pathway | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Research Areas > Cancer | Products > Signaling Pathways > FLT3 | Products > Signaling Pathways > MNK | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-115906
• CAS No.: 422554-29-8
• Molecular Formula: C21H23N3O
• Molecular Weight: 333.43
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source