Nimbolide is a triterpene compound that can be isolated from neem ( Azadirachta indica ), possesses anticancer and antiproliferative activity. Nimbolide induces tumor cell apoptosis by inhibiting NF-κB and CDK4 / CDK6 kinase. Nimbolide suppresses the Wnt , PI3K-Akt, MAPK and JAK-STAT signaling pathways.
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