JH295

Overview

JH295 is a potent, irreversible and selective NIMA-related kinase 2 ( Nek2 ) inhibitor with an IC 50 of 770 nM. JH295 inhibits cellular Nek2 via alkylation of Cys22. JH295 is inactive against the mitotic kinases, Cdk1 , Aurora B or Plk1 , and does not perturb bipolar spindle assembly or the spindle assembly checkpoint. JH295 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > NEKs

Product Information

• Catalog No.: HY-116423
• CAS No.: 1311143-71-1
• Molecular Formula: C18H16N4O2
• Molecular Weight: 320.35
• Purity: 98.66%
• Storage: -20°C, stored under nitrogen * The compound is unstable in solutions, freshly prepared is recommended.
• Availability: In-stock

Source

Original product source