FzM1

Overview

FzM1 is a negative allosteric modulator (NAM) of Frizzled receptor FZD4 . FzM1 reduces WNT5A-dependent WNT responsive element (WRE) activity (log EC 50inh =?6.2). FzM1 binds to an allosteric binding site located in intracellular loop 3 (ICL3) of FZD4 and alters the conformation of the receptor, ultimately inhibiting the WNT/β-catenin cascade.

Application

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Product Information

• Catalog No.: HY-116553
• CAS No.: 1680196-54-6
• Molecular Formula: C21H16N2O2S
• Molecular Weight: 360.43
• Purity: 98.72%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.08 mg/mL (5.77 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source