MAZ51

Overview

MAZ51 is a selective inhibitor of VEGFR-3 (Flt-4) tyrosine kinase. MAZ51 inhibits VEGF-C-induced activation of VEGFR-3 without blocking VEGF-C-mediated stimulation of VEGFR2. MAZ51 had no effect on ligand-induced autophosphorylation of EGFR , IGF-1R and PDGFRβ . MAZ51 blocks proliferation and induces apoptosis in a wide variety of tumor cells. Antitumor activity.

Application

Products | Products > Signaling Pathways > Protein Tyrosine Kinase/RTK | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > VEGFR | Products > Signaling Pathways > Apoptosis

Product Information

• Catalog No.: HY-116624
• CAS No.: 163655-37-6
• Molecular Formula: C21H18N2O
• Molecular Weight: 314.38
• Purity: 99.76%
• Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 0.83 mg/mL (2.64 mM); Clear solution
• Availability: In-stock

Source

Original product source