PIN1 inhibitor API-1

Overview

PIN1 inhibitor API-1 is a specific Pin1 (peptidyl-prolyl cis - trans isomerase NIMA-interacting 1) inhibitor (API-1) with an IC 50 of 72.3 nM. PIN1 inhibitor API-1 directly and specifically binds to the Pin1 peptidyl-prolyl isomerase (PPIase) domain and potently inhibits Pin1 cis - trans isomerizing activity. PIN1 inhibitor API-1 retains the active conformation of pXPO5 and restores the ability of pXPO5 to transport pre-miRNAs from nucleus to cytoplasm, thus up-regulating the anticancer miRNA biogenesis to suppress both in vitro and in vivo hepatocellular carcinoma development.

Application

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Product Information

• Catalog No.: HY-116716
• CAS No.: 680622-70-2
• Molecular Formula: C15H13F3N6O2
• Molecular Weight: 366.30
• Purity: 99.63%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
• Solubility: ≥ 2.17 mg/mL (5.92 mM); Clear solution
• Availability: In-stock

Source

Original product source