YKL-1-116 is a selective and covalent inhibitor of Cdk7 . YKL-1-116 does not target Cdk9 , Cdk12 , or Cdk13 . YKL-1-116 is more potent than THZ1 ( HY-80013 ) toward both Cdk7 WT and Cdk7 as , although Cdk7 as is relatively resistant to this compound as well.
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