UNC1062

Overview

UNC1062 is a highly selective tyrosine kinase ( MERTK ) inhibitor with an IC 50 of 1.1 nM (Morrison K i = 0.33 nM). UNC1062 exhibits good selectivity for the TAM family ( TYRO3 IC 50 = 60 nM, AXL IC 50 = 85 nM). UNC1062 exhibits significant anti-proliferative effects and induces apoptosis in various cancer models (such as melanoma, gastric cancer , and acute myeloid leukemia). UNC1062 inhibits multiple pathways, including MAPK/ERK , PI3K/AKT and JAK/STAT and affects the motility of head and neck squamous cell carcinoma (HNSCC) cells through the RhoA signaling pathway. UNC1062 inhibits macrophage efferocytosis , and it suitable for research on atherosclerosis.

Application

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Product Information

• Catalog No.: HY-117548
• CAS No.: 1350549-36-8
• Molecular Formula: C25H34N6O4S
• Molecular Weight: 514.64
• Purity: 98.92%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source