SPHINX31 is a potent and selective SRPK1 inhibitor, with an IC 50 of 5.9 nM. SPHINX31 inhibits phosphorylation of serine/arginine-rich splicing factor 1 (SRSF1). SPHINX31 also decreases the mRNA expression of pro-angiogenic VEGF -A 165 a isoform. SPHINX31 can be used to research neovascular eye disease.
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