PDK1-IN-2 is a small molecule inhibitor of 3-phosphoinositol-dependent protein kinase-1 ( PDK1 ). PDK1-IN-2 inhibits the binding of PDK1 to its substrate by competitively binding to the PIF pocket of PDK1 , thereby inhibiting the kinase activity and downstream signaling of PDK1 . PDK1-IN-2 can be used for cell survival and proliferation in cancer .
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