MRT00033659

Overview

MRT00033659 is a potent broad-spectrum kinase inhibitor of CK1 ( IC 50 =0.9 μM for CK1δ) and CHK1 ( IC 50 =0.23 μM). MRT00033659, a pyrazolo-pyridine analogue, induces p53 pathway activation and E2F-1 destabilisation.

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Signaling Pathways > Stem Cell/Wnt | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Stem Cells | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > Casein Kinase | Products > Signaling Pathways > Checkpoint Kinase (Chk) | Products > Signaling Pathways > MDM-2/p53 | Products > Signaling Pathways > Early 2 Factor (E2F)

Product Information

• Catalog No.: HY-117857
• CAS No.: 1401731-54-1
• Molecular Formula: C15H14N4O
• Molecular Weight: 266.30
• Purity: 99.77%
• Storage: Powder -20°C, 3 years , 4°C, 2 years * The compound is unstable in solutions, freshly prepared is recommended.
• Solubility: ≥ 4.17 mg/mL (15.66 mM); Clear solution
• Availability: In-stock

Source

Original product source