(Rac)-CCT 250863 (compound rac-21) is a selective and reversible NEK 2 inhibitor with an IC 50 of 0.073 µM. (Rac)-CCT 250863 shows good effects of inducing cell cycle arrest and also can antiproliferative in cells (Pomalidomide sensitive/resistant). (Rac)-CCT 250863 induces apoptosis when combines with Pomalidomide.
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