GSK2245035

Overview

GSK2245035 is a highly potent and selective intranasal Toll-Like receptor 7 ( TLR7 ) agonist with preferential Type-1 interferon (IFN)-stimulating properties. GSK2245035 has pEC 50 s of 9.3 and 6.5 for IFNα and TFNα. GSK2245035 effectively suppresses allergen-induced Th2 cytokine production in human peripheral blood cell cultures. GSK2245035 is used for asthma.

Application

Products | Products > Disease Areas > Pain | Products > Disease Areas > Autoimmune Disease | Products > Disease Areas > Neurological, Eye or Ear Disease | Products > Disease Areas > Inflammation or Immune System Disease | Products > Disease Areas > Cancer | Products > Signaling Pathways > Immunology/Inflammation | Products > Signaling Pathways > Apoptosis | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > Toll-like Receptor (TLR) | Products > Signaling Pathways > IFNAR | Products > Signaling Pathways > TNF Receptor

Product Information

• Catalog No.: HY-118250
• CAS No.: 1207629-49-9
• Molecular Formula: C20H34N6O2
• Molecular Weight: 390.52
• Purity: 99.79%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: ≥ 2.08 mg/mL (5.33 mM); Clear solution
• Availability: In-stock

Source

Original product source