mTOR inhibitor WYE-28 (compound 28) is a selective inhibitor of mTOR ( IC 50 = 0.08 nM). mTOR inhibitor WYE-28 inhibits PI3Kα with an IC 50 value of 6 nM. mTOR inhibitor WYE-28 shows a metabolic time (T 1/2 ) in nude mouse microsomes of 13 min.
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