UNC-2170 maleate

Overview

UNC-2170 maleate is the maleate salt form of UNC-2170 ( HY-115531 ). UNC-2170 maleate is a selective inhibitor for the methyl-lysine binding protein 53BP1 , with IC 50 of 29 µM and K d of 22 µM. UNC-2170 maleate shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB).

Application

Products | Products > Disease Areas > Cancer | Products > Signaling Pathways > Cell Cycle/DNA Damage | Products > Research Areas > Cancer | Products > Research Areas > Cancer > Cancer Targeted Therapy | Products > Research Areas > Cancer > Cancer Metabolism and Metastasis | Products > Signaling Pathways > DNA/RNA Synthesis

Product Information

• Catalog No.: HY-118897
• CAS No.: 2173992-60-2
• Molecular Formula: C18H25BrN2O5
• Molecular Weight: 429.31
• Purity: 99.98%
• Storage: Please store the product under the recommended conditions in the Certificate of Analysis.

Source

Original product source