IW927

Overview

IW927 is a photochemically enhanced TNF-α-TNFR1 interaction inhibitor that blocks the binding of TNF-α to TNFRc1 with an IC 50 value of 50 nM. IW927 binds reversibly to the TNFRc1 with weak affinity ( K d = 40-100 μM), covalently modifies the receptor via a photochemical reaction, and does not bind the related cytokine receptors TNFRc2 or CD40 . IW927 disrupts TNFα-induced IκB phosphorylation with an IC 50 value of 600 nM. IW927 can be used to develop light-independent inhibitors.

Application

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Product Information

• Catalog No.: HY-118922
• CAS No.: 389142-48-7
• Molecular Formula: C22H23N3O3S2
• Molecular Weight: 441.57
• Purity: 99.23%
• Storage: Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Availability: In-stock

Source

Original product source