S18-000003

Overview

S18-000003 is a potent, selective and orally active inhibitor of retinoic acid receptor-related orphan receptor-gamma-t (RORγt) , with an IC 50 of <30 nM towards human RORγt in competitive binding assays. S18-000003 shows selectivity for RORγt over other ROR family members (IC 50 >10 μM). S18-000003 can be used for the research of psoriasis with low risk of thymic aberrations.

Application

Products | Products > Disease Areas > Cancer | Products > Disease Areas > Inflammation or Immune System Disease | Products > Signaling Pathways > Metabolic Enzyme/Protease | Products > Signaling Pathways > Vitamin D Related/Nuclear Receptor | Products > Research Areas > Inflammation/Immunology | Products > Signaling Pathways > ROR

Product Information

• Catalog No.: HY-119366
• CAS No.: 2068119-11-7
• Molecular Formula: C26H25F3N2O4S
• Molecular Weight: 518.55
• Purity: 99.31%
• Storage: Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
• Solubility: 2.5 mg/mL (4.82 mM); Suspended solution; Need ultrasonic
• Availability: In-stock

Source

Original product source